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The medicinal-chemistry programme that produced cagrilintide, described by Kruse and colleagues in the Journal of Medicinal Chemistry in 2021, addressed this by re-engineering the amylin backbone with structural elements borrowed from calcitonin (a related, non-aggregating peptide) and attaching a fatty-acid side chain that enables reversible binding to serum albumin [1]
*Correspondence: Yongjie Zhang, [email protected] These authors have contributed equally to this work
Zinc 5.85 mg )
(20) These findings suggest that liraglutide may exert bone-protective effects by increasing bone formation
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